Detailed Abstract
[Poster - HBP Malignant]
[E-023] Outcomes And Prognostic Factors In Hepatopancreatoduodenectomy
Go-Won CHOI1 , Inhyuck LEE1 , Yoon Soo CHAE1 , Won-Gun YUN1 , Youngmin HAN1 , Young Jae CHO1 , Hye-Sol JUNG1 , Wooil KWON1 , Joon Seong PARK1 , Jin-Young JANG*1
1 General Surgery, 서울대학교병원, REPUBLIC OF KOREA
Background : The high morbidity and mortality of hepatopancreatoduodenectomy (HPD) are major problems. The aim of the study was to describe short-term and long-term outcomes of HPD.
Methods : Patients who underwent HPD in Seoul national university hospital from 2000 to 2023 were included. The patients and tumor characteristics, perioperative and survival outcomes were collected
Results : Total 50 patients were included. 30-day mortality rate was 0% and 90-day mortality rate was 6%. The median overall survival(OS) was 21months and median disease free survival(DFS) was 12months. 5 year survival rate was 16.0%. Morbidity rate was 70.0%. In multivariate analysis, angiolymphatic invasion was an independent prognostic factor for OS and DFS. Adjuvant chemotherapy lowered the risk of OS and adjuvant radiotherapy lowere the risk of DFS. Preoperative CA 19-9 level and total bilirubin level at diagnosis were turned out to be a independent risk factor for patients who had DFS less than 12months.
Conclusions : Despite the high risks associated with HPD, the procedure can be a valuable option for achieving R0 resection in selected patients. Applicability of HPD depends on the rigorous patient selection, precise preoperative assessment, and meticulous perioperative care.
Methods : Patients who underwent HPD in Seoul national university hospital from 2000 to 2023 were included. The patients and tumor characteristics, perioperative and survival outcomes were collected
Results : Total 50 patients were included. 30-day mortality rate was 0% and 90-day mortality rate was 6%. The median overall survival(OS) was 21months and median disease free survival(DFS) was 12months. 5 year survival rate was 16.0%. Morbidity rate was 70.0%. In multivariate analysis, angiolymphatic invasion was an independent prognostic factor for OS and DFS. Adjuvant chemotherapy lowered the risk of OS and adjuvant radiotherapy lowere the risk of DFS. Preoperative CA 19-9 level and total bilirubin level at diagnosis were turned out to be a independent risk factor for patients who had DFS less than 12months.
Conclusions : Despite the high risks associated with HPD, the procedure can be a valuable option for achieving R0 resection in selected patients. Applicability of HPD depends on the rigorous patient selection, precise preoperative assessment, and meticulous perioperative care.
SESSION
Poster
E-Session 09/06 ALL DAY